People

Professor (Special Appointment) at Institute of Emerging Agricultural Technology,Shenzhen University of Advanced Technology. She holds a Ph.D. from the University of Hong Kong and is recognized as a Shenzhen Overseas High-Level Talent.

Her research interest focuses on plant evolutionary genomics and single-cell spatiotemporal omics in developmental biology. She is particularly interested in cell fate determination and gene regulatory networks duringorgan senescence,source-sinkinteraction,nutrient transportation, and root nodule symbiosis.

Dr.Guohasled one National Natural Science Foundation (NSFC) youthscientistproject andcontributed as a corememberinfourothermajor research projects.She has authored40SCI papers, including 24as first or corresponding author, inprestigiousjournals such as Cell, Nature Plants, Developmental Cell, and Nature Communications.

Multi-omicsMethodologicalAdvances:Optimizingtechniques forplant evolutionary genomicsandsingle-cell spatiotemporal omics.

Phylogenomics and Evolution: Understanding trait evolution and function innovation using comparative genomics.

Application of Multi-omics in plant biology: Exploring cell fate determination and gene regulatory networks duringorgan senescence,nutrientallocation, and root nodule symbiosis.

Synthetic Biology in Agriculture: Enhancingnutrienttransport,nitrogenfixationefficiency, andkeyagronomictraitsusingsyntheticbiologyapproaches toboostcropyield.

Education Background

Ph.D. (2011.09 – 2016.12): The University of Hong Kong

Master’s Degree (2008.09 – 2011.06): South China Botanical Garden (CAS)

Bachelor’s Degree (2004.09 – 2008.06): Yunnan University

Professional Experience

2026.06–Present: Professor (Special Appointment), Institute of Emerging Agricultural Technology,Shenzhen University of Advanced Technology

2026.01–2026.03:Researcher, BGI Research-Shenzhen

2022.08–2026.01: Associate Researcher, BGI Research-Shenzhen

2019.07–2022.08:Assistant Researcher, BGI Research-Shenzhen

2016.12–2019.07:Postdoctoral Fellow,The University of Hong Kong

1.Wang, Y., Yan, M., Xie, P., Xing, J.,Fang, D., Wang, X., Zhang, S., Zhang, Y.,Wei, T.^#,Guo, X.^#(2026).Telomere-to-telomere genome and multi-omics analysis provides insights into genomic evolution and nutritional composition ofCanavalia gladiate. Journal of Systematic and Evolution. (accepted)

2.Shao, W.*, Shi, X.*,Guo, X.*, Xiang, S.*, Xiao, Y.*, ... Gu, Y.^#, Yang, J.^#, Liu, H.^#, Xu, X.^#& Wang, E.^#(2026).Spatiotemporal co-transcriptomics uncovers coordinated rhizobia-legume stress programs supporting nitrogen fixation in Medicago. Cell (accepted)

3. Li, Y.*, Kong, L.*,Guo, X.*, …Wei, T.^#, Jiang, Y.^#, Ma, T.^#(2026).A single-nucleus and spatial transcriptomic atlas of poplar leaves reveals the regulation of leaf polarity and cuticle deposition. Journal of Genetics and Genomics

4.Guo, X.*, Wang, Y.*, Zhao, C.*, Tan, C.*, Yan, W.*, ... Liu, H.^#, Guo, H.^#& Xu, X.^#(2025).AnArabidopsissingle-nucleus atlas decodes leaf senescence and nutrient allocation. Cell，188(11), 2856-2871.

5. Dong, Z.*, Liu, X.*,Guo, X.*, Liu, Q.*, Wang, B.*, Shao, W.* ... Liu, H.^#& Yang., X.^#(2025).Developmental innovation of inferior ovaries and flower sex orchestrated by KNOX1 in cucurbits. Nature Plants 1-17.

6. Luo, L.*, Fang, D.*, Wang, F., Lin, Q., Sahu, S.K., Song, Y., ...Hao, G.^#, Liu, H.^#&Guo, X.^#(2024).The chromosome-level genomes of the herbal magnoliidsWarburgia ugandensisandSaururus chinensis. Scientific Data. 11(1), 554.

7. Yao, J.*, Chu, Q.*,Guo, X.*, Shao, W.*, Shang, N., Luo, K., ... Liu, H.^#& Fan, L.^#(2024).Spatiotemporal transcriptomic landscape of rice embryonic cells during seed germination. Developmental Cell. 59(17), 2320-2332.

8. Wang, Y.*, Luo, Y.*,Guo, X.*, Li, Y.*, Yan, J.*, Shao, W., ... Liu, H.^#, Liu, L.^#& Yang, N.^#(2024). A spatial transcriptome map of the developing maize ear. Nature Plants, 1-13.

9. Yang, F.*, Liu, M.*,Guo, X.*, Xu, C., Jiang, J., Mu, W., ... Liu, H.^#& Guo, Y.^#(2024).Signatures of adaptation and purifying selection in highland populations ofDasiphora fruticosa. Molecular Biology and Evolution, 41(6)：msae099

10. Wang, K.*, Zhao, C.*, Xiang, S., ...&Guo, X.^#, Sahu. S.K.^#(2023).An optimized FACS-free single-nucleus RNA sequencing (snRNA-seq) method for plant science research. Plant Science, 326, 111535.

11.Guo X.*, Fang, D.*, Wang, F.* ... & Liu, H.^#(2023). The genome ofAcorusdeciphers insights into early monocot evolution. Nature communications, 14(1), 3662.

12. Li, L.*, Chen, X.*, Fang, D.*, Dong, S.*,Guo, X.*... Zhang, S.^#& Liu, H.^#(2022). Genomes shed light on the evolution ofBegonia, a mega-diverse genus. New phytologist 4: 295-310

13.Guo X.*Fang, D.*, Sahu, S.K.*, ...Soltis, D.E.^#& Liu, H.^#(2021).Chloranthusgenome provides insights into the early diversification of angiosperms. Nature communications 12: 6930

14. Xue, B.*,Guo, X.*, ... & Saunders, R.M.K.(2019). Accelerated diversification correlated with functional traits shape extant diversity of the early divergent angiosperm family Annonaceae. Molecular Phylogenetics and Evolution 142: 106659.

15.Guo, X., ... & Saunders, R.M.K.(2019). A symbiotic balancing act: arbuscular mycorrhizal specificity and specialist fungus gnat pollination in the mycoheterotrophic genusThismia(Thismiaceae). Annals of Botany 124: 331-342

16.Guo, X., Thomas, D.C. & Saunders, R.M.K.(2018). Gene tree discordance and coalescent methods support ancient intergeneric hybridisation betweenDasymaschalonandFriesodielsia(Annonaceae). Molecular Phylogenetics and Evolution 127: 14-29

17.Guo, X., Thomas, D.C. & Saunders, R.M.K.(2018). Organ Homologies and Perianth Evolution in theDasymaschalonAlliance (Annonaceae): Inner Petal Loss and its Functional Consequences. Frontiers in Plant Science 9: art. 174

18.Guo, X., Tang, C.C., Thomas, D.C., Couvreur, T.L.P. & Saunders, R.M.K.(2017). A mega-phylogeny of the Annonaceae: taxonomic placement of five enigmatic genera and recognition of a new tribe, Phoenicantheae. Scientific Reports 7: art. 7323.

19.Guo, X., Hoekstra, P.H.^#... & Saunders, R.M.K.^#(2017). Cutting up the climbers: Evidence for extensive polyphyly inFriesodielsia(Annonaceae) necessitates generic realignment across the tribe Uvarieae. Taxon 66: 3–19.

20.Guo, X., Tang, C.C. & Saunders, R.M.K.(2017). Proposal to conserve the nameFriesodielsiaagainstSchefferomitra(Annonaceae). Taxon 66: 204–205.

21.Guo, X., ... & Saunders, R.M.K.(2014). Reassessing the taxonomic status of two enigmaticDesmosspecies (Annonaceae): morphological and molecular phylogenetic support for a new genus,Wangia. Journal of Systematics and Evolution 52(1):1–15

22.Guo, X., Wang, R., Simmons, M.P., But, P. P.-H., & Yu, J.(2013). Phylogeny of the AsianHedyotis-Oldenlandiacomplex (Spermacoceae, Rubiaceae): evidence for high levels of polyphyly and the parallel evolution of diplophragmous capsules. Molecular Phylogenetics and Evolution 67: 110–122.

23.Guo, X.&. Wang, R.(2011).Hedyotis xinyiensis(Rubiaceae), a new species from China. Annales Botanici Fennici 48: 443–447.

24.Guo, X., ... & Wang, R.(2011). Application of DNA barcodes inHedyotisL. (Spermacoceae, Rubiaceae). Journal of Systematics and Evolution 49(3): 203–212.